What is the effect of rifampin on zolpidem tartrate levels?

What is the effect of rifampin on zolpidem tartrate levels?

• A. Increases levels
• B. Decreases levels
• C. No effect
• D. Requires higher dosage

Answer: (B)

Rifampin is a strong inducer of cytochrome P450 enzymes, particularly CYP3A4. Zolpidem, a sedative-hypnotic medication used for the short-term treatment of insomnia, is primarily metabolized by the CYP3A4 pathway. When rifampin is administered, it accelerates the metabolism of zolpidem, leading to decreased serum levels of the drug. This reduction in zolpidem levels can result in diminished therapeutic effects, requiring careful consideration in dosing and potential adjustments for patients who are concurrently taking these medications. Therefore, the correct understanding is that rifampin decreases zolpidem tartrate levels.

Rifampin is a strong inducer of cytochrome P450 enzymes, particularly CYP3A4. Zolpidem, a sedative-hypnotic medication used for the short-term treatment of insomnia, is primarily metabolized by the CYP3A4 pathway. When rifampin is administered, it accelerates the metabolism of zolpidem, leading to decreased serum levels of the drug. This reduction in zolpidem levels can result in diminished therapeutic effects, requiring careful consideration in dosing and potential adjustments for patients who are concurrently taking these medications. Therefore, the correct understanding is that rifampin decreases zolpidem tartrate levels.