What is the therapeutic range for lithium in mEq/L?

What is the therapeutic range for lithium in mEq/L?

• A. 0.5-1.0
• B. 0.8-1.2
• C. 1.2-1.5
• D. 1.5-2.0

Answer: (B)

The therapeutic range for lithium is typically defined as 0.8-1.2 mEq/L. This range is critical for ensuring the drug provides its antidepressant and mood-stabilizing effects while minimizing the risk of toxicity. Lithium has a narrow therapeutic window, meaning that concentrations above this range can lead to adverse effects, including tremors, nausea, and even seizures. Clinicians monitor serum lithium levels closely to maintain them within this therapeutic range, as fluctuations can impact efficacy and safety. Monitoring takes on added importance due to the pharmacokinetics of lithium and individual patient factors that can influence drug clearance and response.

The therapeutic range for lithium is typically defined as 0.8-1.2 mEq/L. This range is critical for ensuring the drug provides its antidepressant and mood-stabilizing effects while minimizing the risk of toxicity. Lithium has a narrow therapeutic window, meaning that concentrations above this range can lead to adverse effects, including tremors, nausea, and even seizures. Clinicians monitor serum lithium levels closely to maintain them within this therapeutic range, as fluctuations can impact efficacy and safety. Monitoring takes on added importance due to the pharmacokinetics of lithium and individual patient factors that can influence drug clearance and response.