What is the therapeutic range of valproate in mcg/mL?

What is the therapeutic range of valproate in mcg/mL?

• A. 10-50 mcg/mL
• B. 25-75 mcg/mL
• C. 50-100 mcg/mL
• D. 100-150 mcg/mL

Answer: (C)

Valproate, also known as valproic acid, is a medication commonly used to treat various seizure disorders, bipolar disorder, and to prevent migraines. Its therapeutic range is crucial for achieving optimal efficacy while minimizing toxicity. The correct therapeutic range for valproate is 50-100 mcg/mL. This range allows for adequate control of seizures and mood stabilization. Levels below this range may not be effective for treatment, while levels above can lead to adverse side effects such as tremors, weight gain, and hepatic toxicity. In clinical practice, monitoring valproate levels helps ensure that patients maintain drug concentrations within this therapeutic window, which is essential for their safety and treatment success. Other ranges provided in the options do not reflect the consensus among guidelines for valproate therapy, further underscoring that 50-100 mcg/mL is the established therapeutic range.

Valproate, also known as valproic acid, is a medication commonly used to treat various seizure disorders, bipolar disorder, and to prevent migraines. Its therapeutic range is crucial for achieving optimal efficacy while minimizing toxicity. The correct therapeutic range for valproate is 50-100 mcg/mL.

This range allows for adequate control of seizures and mood stabilization. Levels below this range may not be effective for treatment, while levels above can lead to adverse side effects such as tremors, weight gain, and hepatic toxicity.

In clinical practice, monitoring valproate levels helps ensure that patients maintain drug concentrations within this therapeutic window, which is essential for their safety and treatment success. Other ranges provided in the options do not reflect the consensus among guidelines for valproate therapy, further underscoring that 50-100 mcg/mL is the established therapeutic range.